Vampire doc, Dr. Gabriella Van Court, is content mingling with mortals at Fang Hospital. In love with a mortal colleague, Dr. Maxwell Cade, she's happy to stay a closeted vampire. She thought she was safe in the New World and away from her evil progenitor, Volk, who had vowed to find her and make her his queen. That is until her uncle, who she thought was "vampire dead", shows up in her ER after Volk attempts to assassinate him, preventing him from warning Gabriella that he is coming to get her. While battling Volk, Gabriella risks not only her "vampire life", but also revealing the truth about her immortality to Max.